engineering.princeton.edu, November 29, 2018
by Adam Hadhazy
@brangwynnelab
Love this piece. It may be trivial, in hindsight, that principles of soft matter physics apply to cell biology. Great it now gets the attention it deserves. Kudos to @HymanLab @brangwynnelab @GladfelterLab @PappulabWashU, and others.
Cell biology befriends soft matter physics
Phase separation creates complex condensates in eukaryotic cells. To study these mysterious droplets, many disciplines come together.
www.nature.com
"Cell Biology Befriends Soft Matter Physics". Nice article on condensate field in Nature Methods, with quotes from Cliff, @GladfelterLab @PappulabWashU @HymanLab and many others.
Cell biology befriends soft matter physics
Phase separation creates complex condensates in eukaryotic cells. To study these mysterious droplets, many disciplines come together.
www.nature.com
A project from @EPrinceton's prof. Clifford Brangwynne (@brangwynnelab), @PrincetonMolBio's prof. @MartinWuhr and @PrincetonChem's prof. Tom Muir (@Muirlab) aims to unlock our understanding of cellular structures and eventually inform design & testing of new drugs & therapies.
What interactions drive phase separation in cells? We in @supersciencejew et al show heterotypic interactions, e.g. between RNA & protein, are key to cohesivity of liquid condensates, shattering several assumptions in LLPS field
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Composition-dependent thermodynamics of intracellular phase separation
Heterotypic multicomponent interactions are shown to dominate the liquid–liquid phase separation that enables the formation of intracellular con...
www.nature.com
HIGHLIGHTS
New tools illuminate the liquid forces at play in living cells
Cliff wins MacArthur ‘Genius’ Grant
Cliff selected as HHMI Investigator
Cell Biology’s New Phase
Nature, March 15, 2018
by Elie Dolgin
